These optimizations are difficult to implement, frequently error-prone, and lead to inconsistent behavior across runtimes. Bun's "Direct Streams" optimization takes a deliberately and observably non-standard approach, bypassing much of the spec's machinery entirely. Cloudflare Workers' IdentityTransformStream provides a fast-path for pass-through transforms but is Workers-specific and implements behaviors that are not standard for a TransformStream. Each runtime has its own set of tricks and the natural tendency is toward non-standard solutions, because that's often the only way to make things fast.
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但这种垄断格局，即将被打破，多款在研新药正从作用机制到给药方式，向Vosoritide发起挑战。Ascendis的TransCon-CNP通过包裹技术延长了药物作用时间，实现了周剂给药，目前正处于FDA审批阶段；而BridgeBio的口服药Infigratinib，则从作用机制到用药体验实现全面突破。
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provide suggestions for optimizing individual pages
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